Preclinical Imaging Facility (PIF)

Preclinical Imaging Facility (PIF) is a small animal imaging hub at Flemingsberg campus and a part of the Preclinical Laboratory (PKL). PIF together with PKL provides a full range of preclinical study services for academia and industry sectors, providing them with high quality preclinical study data.

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Our objectives

  • State of art small animal imaging techniques for researchers who are eager to translate their scientific findings in the laboratory from bench side to bed side.
  • Multiple imaging modalities are available in PIF, include luminescence imaging, fluorescence imaging, micro-computer tomography (u-CT), micro-ultrasound, photoacoustic imaging, positron emission tomography (PET) and magnetic resonance imaging (MRI).
  • The combination of multiple imaging modalities in preclinical studies will help the researchers to understand the molecular, cellular and physiological changes in living animals and to predict the outcome of new treatments in patients.
  • At the same time, PIF also helps researchers to fulfill 3R (Refine, Reduce and Replace) requirement in their animal studies, by repeat measurement in the same living animals.

 

Our services

  • One-stop multimodal small animal imaging service
  • Hands-on technical support in small animal imaging acquisition
  • Post-image analysis and validation
  • Instant consultant on imaging applications and experimental design
  • Support in ethical permit application, grant application and manuscript preparation

 

Our instruments

  • IVIS spectrum (PerkinElmer)
  • Quantum FX CT (PerkinElmer)
  • Vevo LAZR (FujiFilm VisualSonics)
  • nanoScan PET/MRI (Mediso)

 

Our software

  • Living image
  • Analyze
  • Vevo Lab: Vevo Strain & Vevo CQ
  • Interview Fusion
  • VivoQuant

 

Available Imaging Techniques

  • Bioluminescence Imaging (BLI)
  • Fluorescence Imaging (FI)
  • Micro-Computer Tomography (u-CT)
  • High-Frequency Micro-Ultrasound (u-US)
  • Photoacustic Imaging (PA)
  • Positron Emission Tomography (PET)
  • Magnetic Resonance Imaging (MRI)
  • Multimodality Co-Registration

 

Applications

  • Oncology: tumor-size quantification, metastasis, perfusion and hypoxia
  • Molecular biology: Biomarker distribution, probe development
  • Neurobiology: stroke, blood-brain barrier disruption
  • Ischemia and reperfusion
  • Cardiology: cardiac structure and function, blood flow, perfusion
  • Cellular therapy and regenerative medicine: cell tracking, response to therapy
  • Drug development: distribution, pharmacokinetics
  • Bone/fat analysis

 

See also

 

Contact

Email: pkl5.karolinska@sll.se